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Identified cellular targets through which PKA activation produces a bronchodilator effect include: MLCK: Phosphorylation of myosin light chain kinase (MLCK) by cAMP-dependent protein kinase (PKA) decreases the affinity of the kinase for Ca2+ and calmodulin , resulting in a decrease in MLCK activity

TB-500 is the synthetic form of the naturally occurring polypeptide Thymosin Beta-4 (T4)

For more information Action Medical Research updates on this project: Data availability This study includes no data deposited in external repositories

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